Preimplantation Genetic Treatment

Personalised Fertility Solutions

Preimplantation Genetic Treatment (PGT)

Pre-implantation Genetic Treatment (PGT) represents a significant advancement in assisted reproductive technology, offering prospective parents deeper insights into the genetic health of embryos before implantation. This screening process is seamlessly integrated with In Vitro Fertilisation (IVF), helping reduce the risk of passing on inherited genetic disorders and improving the chances of a healthy pregnancy.

Pre-implantation Genetic Testing (PGT) is used during IVF to screen embryos for chromosomal abnormalities before transfer. This helps improve the chances of selecting an embryo with the highest potential for healthy development. PGT uses Next Generation Sequencing (NGS), a highly sensitive platform that analyses each embryo’s genetic structure. It can detect missing, extra, or rearranged chromosomes that may affect implantation or increase the risk of miscarriage. By identifying embryos with a normal chromosome count, PGT supports safer, more informed embryo selection during IVF.

PGT is especially beneficial for individuals or couples facing known genetic challenges like cystic fibrosis or Huntington's disease, as it enables targeted screening for specific gene mutations. It is also a valuable option for those dealing with concerns such as advanced maternal age, recurrent pregnancy loss, or repeated IVF failures. By delivering this level of precision, PGT empowers informed decision-making and improves the chances of a successful, healthy pregnancy.

At NG GyneHealth, we are committed to guiding you through the PGT process with compassion and expertise, providing personalised support to ensure you feel confident and informed every step of the way.

How Next Generation Sequencing (NGS) Work:

Pre-implantation Genetic Testing (PGT) uses advanced screening technology to examine the genetic health of embryos before transfer. One of the most accurate and reliable tools used in this process is Next Generation Sequencing (NGS).

The process begins with an IVF or ICSI cycle, where eggs are collected from the ovaries and fertilised with sperm in a laboratory setting. Embryos are grown until the blastocyst stage, typically five or six days after fertilisation.

At this point, a small number of cells are carefully removed from the trophectoderm, the outer layer of the embryo, using a laser. This biopsy is designed to minimise disruption to development. After the biopsy, the embryos are frozen while the cells are sent for genetic testing.

NGS scans each sample to detect missing, extra, or rearranged chromosomes. Results are typically ready within 7 to 10 days, at which point your fertility specialist can recommend an embryo without detectable chromosomal abnormalities for transfer.

PGT with NGS may be recommended for individuals or couples who have:

A known genetic or chromosomal condition
A history of repeated IVF attempts
Experienced multiple miscarriages
Age-related fertility concerns

By using NGS, Dr Naguesh Gaunekar and Dr Sally Rodrigues can provide a clearer picture of embryo health and guide personalised decisions throughout your IVF treatment.

Thorough Screening

Pre-implantation Genetic Testing (PGT) allows us to assess the genetic health of embryos before transfer. This screening helps identify certain conditions that may affect implantation or early development. PGT can detect:

Chromosomal abnormalities

Checks for missing or extra chromosomes (aneuploidy), which may interfere with implantation or increase the risk of miscarriage. This is also known as PGT-A.

Single-gene conditions

Screens for specific inherited disorders, such as cystic fibrosis, Huntington’s disease, or Duchenne muscular dystrophy. This form of testing is referred to as PGT-M.

Structural chromosome rearrangements

Detects known translocations or other structural changes that may affect embryo development. This is called PGT-SR.

These insights help guide embryo selection, allowing your care team to make more informed decisions during IVF.

Targeted Insights

For families concerned about specific genetic issues like cystic fibrosis or Huntington’s disease, this technology allows us to check for particular gene mutations, providing more confidence and peace of mind.

Clearer Path Forward

If you’re facing challenges like recurrent pregnancy loss, advanced maternal age, or previous IVF setbacks, this approach offers you the answers and personalised support you need.

Is PGT the Right Option for You?

While Pre-implantation Genetic Testing (PGT) can provide helpful insight during IVF, it's important to understand what the process involves and where it may apply.

Pre-implantation Genetic Testing does not guarantee a pregnancy
In some cases, testing may reduce the number of embryos available for transfer
The decision to proceed should always involve careful discussion with your fertility specialist and a qualified genetics team

Pre-implantation Genetic Testing with Next Generation Sequencing may be particularly valuable for individuals or couples with a known genetic condition, a history of IVF failure, repeated miscarriage, or concerns related to age. For others, it may not be necessary.

Thinking about IVF and want to know if PGT is right for you?

Speak with NG GyneHealth fertility specialists Dr Naguesh Gaunekar and Dr Sally Rodrigues. They’ll guide you through your options with expert advice, so you can move forward with clarity and confidence.

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